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KMID : 1149220220300030137
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Korean Journal of Oriental Medical Prescription
2022 Volume.30 No. 3 p.137 ~ p.143
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Forsythiae suspensa regulates SREBP-1c signaling pathway as mediated with LXR alpha nuclear orphan receptor
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Kim Young-Eun
Park Sun-Dong
Kim Young-Woo
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Abstract
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Objectives : Brain-Liver axis is an important target of the chronic human diseases. Hepatic steatosis is one of the most famous disorders in the chronic diseases. This study investigated the moderating effect of beneficial herbs on the fat accumulation, which is mediated by the LXR alpha-SREBP-1c signaling pathway.
Methods : In order to confirm the SREBP-1c inhibitory effect, we performed immonoblotting ananlysis using HepG2 cells and Huh 7 cells treated by T0901317, the ligand of LXRα.
Results : Forsythiae suspensa water extract (FSE) was not cytotoxicity in cell lines. FSE inhibited SREBP-1c protein expression in HepG2 and Huh7 cells induced by T0901317. In addition, FSE increased the phosphorylation of LKB1, which is associated with LXR-related pathway in HepG2 and Huh 7 cells.
Conclusions : These results showed that FSE activated LKB1 to suppress SREBP-1c, which protects the cells against oxidative stress.
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KEYWORD
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LXR, SREBP-1c, Forsythiae suspensa, oxidative stress
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